FACTS ABOUT PKRRATING REVEALED

The interfacial residues are very conserved amongst eIF2α kinases and mutagenesis implicates the BTB dimer in PKR function18. FRET measurements display which the kinase domains dimerize when PKR binds to activating dsRNAs19. These observations support a model in which activating RNA serves as being a scaffold to bind several PKR monomers, raising

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